• Guest
HabraHabr
  • Main
  • Users

  • Development
    • Programming
    • Information Security
    • Website development
    • JavaScript
    • Game development
    • Open source
    • Developed for Android
    • Machine learning
    • Abnormal programming
    • Java
    • Python
    • Development of mobile applications
    • Analysis and design of systems
    • .NET
    • Mathematics
    • Algorithms
    • C#
    • System Programming
    • C++
    • C
    • Go
    • PHP
    • Reverse engineering
    • Assembler
    • Development under Linux
    • Big Data
    • Rust
    • Cryptography
    • Entertaining problems
    • Testing of IT systems
    • Testing Web Services
    • HTML
    • Programming microcontrollers
    • API
    • High performance
    • Developed for iOS
    • CSS
    • Industrial Programming
    • Development under Windows
    • Image processing
    • Compilers
    • FPGA
    • Professional literature
    • OpenStreetMap
    • Google Chrome
    • Data Mining
    • PostgreSQL
    • Development of robotics
    • Visualization of data
    • Angular
    • ReactJS
    • Search technologies
    • Debugging
    • Test mobile applications
    • Browsers
    • Designing and refactoring
    • IT Standards
    • Solidity
    • Node.JS
    • Git
    • LaTeX
    • SQL
    • Haskell
    • Unreal Engine
    • Unity3D
    • Development for the Internet of things
    • Functional Programming
    • Amazon Web Services
    • Google Cloud Platform
    • Development under AR and VR
    • Assembly systems
    • Version control systems
    • Kotlin
    • R
    • CAD/CAM
    • Customer Optimization
    • Development of communication systems
    • Microsoft Azure
    • Perfect code
    • Atlassian
    • Visual Studio
    • NoSQL
    • Yii
    • Mono и Moonlight
    • Parallel Programming
    • Asterisk
    • Yandex API
    • WordPress
    • Sports programming
    • Lua
    • Microsoft SQL Server
    • Payment systems
    • TypeScript
    • Scala
    • Google API
    • Development of data transmission systems
    • XML
    • Regular expressions
    • Development under Tizen
    • Swift
    • MySQL
    • Geoinformation services
    • Global Positioning Systems
    • Qt
    • Dart
    • Django
    • Development for Office 365
    • Erlang/OTP
    • GPGPU
    • Eclipse
    • Maps API
    • Testing games
    • Browser Extensions
    • 1C-Bitrix
    • Development under e-commerce
    • Xamarin
    • Xcode
    • Development under Windows Phone
    • Semantics
    • CMS
    • VueJS
    • GitHub
    • Open data
    • Sphinx
    • Ruby on Rails
    • Ruby
    • Symfony
    • Drupal
    • Messaging Systems
    • CTF
    • SaaS / S+S
    • SharePoint
    • jQuery
    • Puppet
    • Firefox
    • Elm
    • MODX
    • Billing systems
    • Graphical shells
    • Kodobred
    • MongoDB
    • SCADA
    • Hadoop
    • Gradle
    • Clojure
    • F#
    • CoffeeScript
    • Matlab
    • Phalcon
    • Development under Sailfish OS
    • Magento
    • Elixir/Phoenix
    • Microsoft Edge
    • Layout of letters
    • Development for OS X
    • Forth
    • Smalltalk
    • Julia
    • Laravel
    • WebGL
    • Meteor.JS
    • Firebird/Interbase
    • SQLite
    • D
    • Mesh-networks
    • I2P
    • Derby.js
    • Emacs
    • Development under Bada
    • Mercurial
    • UML Design
    • Objective C
    • Fortran
    • Cocoa
    • Cobol
    • Apache Flex
    • Action Script
    • Joomla
    • IIS
    • Twitter API
    • Vkontakte API
    • Facebook API
    • Microsoft Access
    • PDF
    • Prolog
    • GTK+
    • LabVIEW
    • Brainfuck
    • Cubrid
    • Canvas
    • Doctrine ORM
    • Google App Engine
    • Twisted
    • XSLT
    • TDD
    • Small Basic
    • Kohana
    • Development for Java ME
    • LiveStreet
    • MooTools
    • Adobe Flash
    • GreaseMonkey
    • INFOLUST
    • Groovy & Grails
    • Lisp
    • Delphi
    • Zend Framework
    • ExtJS / Sencha Library
    • Internet Explorer
    • CodeIgniter
    • Silverlight
    • Google Web Toolkit
    • CakePHP
    • Safari
    • Opera
    • Microformats
    • Ajax
    • VIM
  • Administration
    • System administration
    • IT Infrastructure
    • *nix
    • Network technologies
    • DevOps
    • Server Administration
    • Cloud computing
    • Configuring Linux
    • Wireless technologies
    • Virtualization
    • Hosting
    • Data storage
    • Decentralized networks
    • Database Administration
    • Data Warehousing
    • Communication standards
    • PowerShell
    • Backup
    • Cisco
    • Nginx
    • Antivirus protection
    • DNS
    • Server Optimization
    • Data recovery
    • Apache
    • Spam and antispam
    • Data Compression
    • SAN
    • IPv6
    • Fidonet
    • IPTV
    • Shells
    • Administering domain names
  • Design
    • Interfaces
    • Web design
    • Working with sound
    • Usability
    • Graphic design
    • Design Games
    • Mobile App Design
    • Working with 3D-graphics
    • Typography
    • Working with video
    • Work with vector graphics
    • Accessibility
    • Prototyping
    • CGI (graphics)
    • Computer Animation
    • Working with icons
  • Control
    • Careers in the IT industry
    • Project management
    • Development Management
    • Personnel Management
    • Product Management
    • Start-up development
    • Managing the community
    • Service Desk
    • GTD
    • IT Terminology
    • Agile
    • Business Models
    • Legislation and IT-business
    • Sales management
    • CRM-systems
    • Product localization
    • ECM / EDS
    • Freelance
    • Venture investments
    • ERP-systems
    • Help Desk Software
    • Media management
    • Patenting
    • E-commerce management
    • Creative Commons
  • Marketing
    • Conferences
    • Promotion of games
    • Internet Marketing
    • Search Engine Optimization
    • Web Analytics
    • Monetize Web services
    • Content marketing
    • Monetization of IT systems
    • Monetize mobile apps
    • Mobile App Analytics
    • Growth Hacking
    • Branding
    • Monetize Games
    • Display ads
    • Contextual advertising
    • Increase Conversion Rate
  • Sundry
    • Reading room
    • Educational process in IT
    • Research and forecasts in IT
    • Finance in IT
    • Hakatonas
    • IT emigration
    • Education abroad
    • Lumber room
    • I'm on my way

How to reduce the number of experiments on animals

Continuing previous topic about implants and prosthetics 3r3-360. An interesting technology of laboratory studies of the behavior of an orthopedic implant in conditions as close as possible to the human body was proposed by the same scientific group. The study can be conducted in vitro - that is, without the participation of laboratory animals.


 3r366.
3r360.
 3r366. Endoprosthetics - replacing a damaged joint or bone with a high-tech prosthesis is a complex operation, using the most advanced metal, ceramic and polymeric materials.
 3r366.
 3r366. Any material for the implant passes a series of checks, including the biocompatibility and behavior of the material under mechanical stress. Since the results of such studies in traditional laboratory conditions are very different from actual indicators of wear, to test the implant's behavior in a living organism, it is implanted into the body of a laboratory animal. After some time, usually about a year, the implant is removed and the biocompatibility and aging of the material are evaluated.
 3r366.
 3r366. Scientists from the Center for Composite Materials NITU "MISiS" together with colleagues from the Technical University of Dortmund developed a technology to predict the wear of the prosthesis material under mechanical load in an environment close to real. Especially synthesized fluid that mimics the plasma of human blood, and high-tech servo-hydraulic installation completely replaced the experimental living sample.
 3r366.
 3r366. As a research material was used developed by scientists from the Center for Composite Materials NUST "MISiS" biomimetic ultrahigh-molecular polyethylene.
 3r366.
 3r366.
“We provided material and suggested using synthetic plasma, and our colleagues from the Technical University of Dortmund developed fatigue testing technology and conducted an experiment on their equipment,” comments Fyodor Senatov, Ph.D. - The material was subjected to two types of mechanical load, imitating the load of the femoral and tibial bones: cyclic and static. Thanks to this experiment, we proved that it is possible to predict the in vitro behavior of an orthopedic implant under conditions of a human body, without resorting to animal testing. ”
 3r366. 3r3334.
 3r366.
“Our desire was to offer an alternative that would reduce the number of tests on animals, which, from the point of view of assessing fatigue properties, are ineffective and questionable from the point of view of ethics. Another aspect was the ability to offer a new method that would allow the implant material to be tested for durability in the laboratory. In the global practice, so far there are no standards for the study of the fatigue properties of implants in the biomimetic environment, which is associated with great risks of using new materials. We work in the development of tests that allow you to accurately predict the life of the material. Similar experiments have already been carried out by the group of Professor Walter (for example, the head of the research group on the German side) for metal and ceramic implants. For polymers, this experiment is still unique, and has no world analogues, ”says Marina Knyazeva, a representative of the research group of the Technical University of Dortmund.
 3r366.
 3r366. Another significant advantage of the research technology proposed by scientists is the saving of time. If it can take about a year to assess the chemical aging of an implant in a living organism, then it takes decades to test for durability. In vitro, the process of chemical aging and wear can be significantly accelerated. If the indicators of material wear are unsatisfactory, this will become quickly known, and it will be possible to continue experiments with other samples.
 3r366.
 3r366. However, it’s too early to talk about the complete rejection of the role of laboratory animals in testing materials for prosthetics.
 3r366.
 3r366.
“Our technology will make it possible to compare several materials at once, without testing any of them on animals. However, when the most optimal material from the list is found, it will need to be tested already in vivo - in living organisms. This is due, above all, to the need to check the biocompatibility of the material, as well as its orthopedic parameters - after all, patients can meet a variety of features of the musculoskeletal system, “- explains Fedor Senates.
 3r366. Thus, scientists propose an integrated technology to study the behavior of an implant, where experiments on accelerated aging in vitro will predict the life of a potential implant, and subsequent in vivo tests will show its biocompatibility.
 3r366.
 3r366. The original article can be found in
Journal of the Mechanical Behavior of Biomedical Materials
.
3r366. 3r366.
! function (e) {function t (t, n) {if (! (n in e)) {for (var r, a = e.document, i = a.scripts, o = i.length; o-- ;) if (-1! == i[o].src.indexOf (t)) {r = i[o]; break} if (! r) {r = a.createElement ("script"), r.type = "text /jаvascript", r.async =! ? r.defer =! ? r.src = t, r.charset = "UTF-8"; var d = function () {var e = a.getElementsByTagName ("script")[0]; e.parentNode.insertBefore (r, e)}; "[object Opera]" == e.opera? a.addEventListener? a.addEventListener ("DOMContentLoaded", d,! 1): e.attachEvent ("onload", d ): d ()}}} t ("//mediator.mail.ru/script/2820404/"""_mediator") () (); 3r3365. 3r366.

It may be interesting

  • Comments
  • About article
  • Similar news
This publication has no comments.

weber

Author

11-10-2018, 10:31

Publication Date

Development / Programming

Category
  • Comments: 0
  • Views: 252
Attackers have learned to bypass the
The intervertebral discs are
Flexbox. Infographics on technology
CoLaboratory: Android Night #Apple
Scientists for the first time
A wireless power system has been
Write a comment
Name:*
E-Mail:


Comments
I know your aptitude on this. I should say we ought to have an online discourse on this. Composing just remarks will close the talk straight away! What's more, will confine the advantages from this data. 審計 報告

Today, 15:43

nushra45

Great job for publishing such a beneficial web site. Your web log isn’t only useful but it is additionally really creative too. There tend to be not many people who can certainly write not so simple posts that artistically. Continue the nice writing香港利得稅

Today, 15:02

nushra45

I definitely enjoying every little bit of it. It is a great website and nice share. I want to thank you. Good job! You guys do a great blog, and have some great contents. Keep up the good work. 먹튀
Today, 14:46

seo servise

If you are looking for more information about flat rate locksmith Las Vegas check that right away.  best front load washing machine in india
Today, 13:15

jacksonseo


Here we introduce our top coupons that will help you for online shopping at discountable prices.Revounts bring you the best deals that slash the bills.If you are intrested in online shopping and want to save your savings then visit our site for best experience.
Today, 08:41

Emma Taylor

Adv
Website for web developers. New scripts, best ideas, programming tips. How to write a script for you here, we have a lot of information about various programming languages. You are a webmaster or a beginner programmer, it does not matter, useful articles will help to make your favorite business faster.

Login

Registration Forgot password