We only fight with death, and you? Or companies that develop fantastic medicine

We only fight with death, and you? Or companies that develop fantastic medicine
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 3r33434. Hi, Habr!
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 3r33434. I want to talk about companies engaged in development and research in the field of age-related and aging diseases. It seems to me that it is necessary to draw people's attention to the problems of medicine, health care and aging in general, since these problems bring enormous harm to humanity in all its spheres. Aging and death are those things that unite humanity, no matter what your world view, material condition, status, race, age or health. Immediately I warn you that there may be many new and incomprehensible terms ahead, even though I tried to decipher all these terms. Biotechnology company 3r3434. , which develops and introduces cellular medicine (cell therapy) in order to use new methods for the treatment of autoimmune and degenerative diseases, immuno-oncology and functional regeneration. The methods are based on the use of stem cells derived from the placenta. At the moment, there are already products on the market: BIOVANCE - allograft (common name for drugs and drugs intended for peresekka organs and tissues), intended for use as a biological membrane membrane that preserves the extracellular matrix (tissue substances located outside the cell) and supports the restoration of damaged tissue, consists of amniotic (placental) cells; Interfyl is also an allotransplant, which is also based on placenta cells, and is also used for tissue regeneration.
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 3r33434. 3r33418. 3. BlueRock Therapeutics. Country: Canada | Funding: $ 225M. 3r33434.
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Company
founded in 2016. The main goal is the development of regenerative drugs for intractable diseases. The company is developing the Cell + Gene platform, which is designed for the production and supply of native cellular and engineering cellular therapies. They use for development pluripotent stem cells 3r3434. (that is, cells that can eventually differentiate into all cell types, except placental cells and the yolk sac).
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 3r33434. 3r33418. 4. Unity Biotechnology. Country: USA | Funding: $ 208.3M. 3r33434.
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 3r33434. 3r3104.
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 3r33434. The main objective
Companies 3r3434. - elimination of accumulated 3r3111. aging cells 3r3434. (senescent cells (SnCs)). Treatment methods are being developed to selectively eliminate aging cells, to stop, slow down or reverse age-related disease and restore tissue to a more functional and healthy state. More specifically, the company has a pipeline with the following areas: treatment of the human musculoskeletal system (focus on osteoarthritis), treatment of ophthalmologic diseases (product code-named UBX196? which is an inhibitor of specific members of the family of regulatory proteins of apoptosis
Bcl-2
( suppress apoptosis)).
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 3r33434. 3r33418. 5. Osiris Therapeutics. Country: USA | Funding: $ 65M. 3r33434.
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 3r33434. 3r3125.
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 3r33434. 3r33130. Osiris Therapeutics
- A stem cell company for regenerative medicine aimed at treating inflammatory, cardiovascular, orthopedic diseases and wound healing. The following products already exist:
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 3r33434. Grafix - cryopreserved placental membrane consisting of extracellular matrix (collagen, fibroblasts, mesenchymal stem cells, epithelial cells);
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 3r33434. Cartiform - allograft of articular cartilage repair;
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 3r33434. BIO4 - is a bone matrix consisting of mesenchymal stem cells, osteoblast and osteoprogenator cells (cells that form osteoblasts);
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 3r33434. Stravix is ​​a cryopreserved placental tissue.
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 3r33434. 3r33418. 6. resTORbio. Country: USA | Funding: $ 65M. 3r33434.
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 3r33434. 3r3158.
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 3r33434. Company founded in 2016. In the company name you can see the abbreviation TOR. I will not bother too much and take the definition from Wikipedia: "3r-3389. The target of mammalian rapamycin 3r-3390. (Target target of rapamycin (TOR); mammalian target of rapamycin (mTOR); FK506 binding protein 12-rapamycin associated protein 1 (FRAP1)) - serine-threonine specificity kinase, which exists in the cell as a subunit of intracellular multimolecular signaling complexes TORC1 and TORC2. As part of these complexes, TOR regulates cell growth and survival. The TORC1 complex is targeted by the rapamycin immuno-suppressant (this explains the name of the protein “rapamycin target”). ” Studies have been conducted that have proven the effect of mTOR on aging. That is, aging is not only cellular depreciation, but also complex specific intracellular processes, one of which is mTOR. In addition, presumably, TORC1 affects the various systems of the body regarding the aging of these systems. However, TORC2 works the other way around, that is, it reduces life expectancy. This company has developed a method in which mTOR “tunes to the mode” of TORC1 inhibition without inhibiting TORC2.
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 3r33434. 3r33418. 7. Alkahest. Country: USA | Funding: $ 50M. 3r33434.
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 3r33434. 3r33177.
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 3r33434. 3r3182. Company
engaged in the development of therapy aimed at working with components of human blood. The company has identified specific proteins (chronokines), which increase with aging, as well as those proteins that decrease with aging. Chronokines, which reduce the likelihood of developing age-related diseases, are candidates for replacement or addition, while “bad” chronokines are supposed to be inhibited or deleted. Currently, the company is developing two drugs, code-named AKST /GRF6019 and AKST4290.
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 3r33434. 3r33418. 8. Calico. Country: USA | Funding: $ 1.5B. 3r33434.
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 3r33434. 3r3194.
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 3r33434. 3r-33199. Calico 3r3434. (California life company) is a company owned by Alphabet, whose mission is to use advanced technology to improve the understanding of biology that controls longevity. The company is suitable with an interdisciplinary and long-term focus on research. Founded in 2013. Probably, they would be worth to tell more.
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 3r33434. 3r33418. 9. Alzheon. Country: USA | Funding: $ 37M. 3r33434.
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 3r33434. Alzheon is developing a drug with the code name ALZ-80? which, according to current research, is well tolerated and may slow down the course of the disease in Alzheimer's patients.
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 3r33434. 3r33418. 10. Neuraly. Country: USA | Funding: $ 36M. 3r33434.
 3r33434. Neuraly is a subsidiary of the biotech company at the Johns Hopkins School of Medicine and is committed to providing the first disease modifying agent for neurodegenerative disorders and aging.
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 3r33434. 3r33418. 11. Elysium. Country: USA | Funding: $ 28M. 3r33434.
 3r33434. The main goal of the company is to solve problems in the field of healthcare with the help of science. At the moment, there are various studies that are related to the physiology of the skin, microbiome, muscles, cognitive functions and circadian rhythm.
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 3r33434. 3r33418. 12. Nuritas. Country: Ireland | Funding: € 23.9M. 3r33434.
 3r33434. Nuritas uses artificial intelligence and genomics for research on so-called bioactive peptides. Bioactive peptides (BP) are organic substances formed by amino acids linked by covalent bonds, known as amide or peptide bonds. Although some BPs exist for free in their natural source, the vast majority of known BPs are encoded in the structure of the parent proteins and are released mainly by enzymatic processes. Some BP were obtained by chemical synthesis. PD plays an important role in human health by acting on the digestive, endocrine, cardiovascular, immune and nervous systems. BP is considered to be the biologically active regulators of the new generation; they can prevent oxidation and microbial degradation in foods, as well as improve the treatment of various diseases and disorders, thereby improving the quality of life.
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 3r33434. 3r33418. 13. Samumed. Country: USA. 3r33434.
 3r33434. Work 3r33252. Companies 3r3434. trends in the fight against cancer and research in regenerative medicine. There is a so-called Wnt signaling pathway, which is one of the intracellular signaling pathways that regulates cell embryogenesis and the development of malignant tumors. Samumed develops treatments for diseases based on the management of this signaling pathway. The company has already discovered many new biological processes related to the Wnt pathway, identified new biological targets and developed low molecular weight drugs that affect Wnt activity.
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 3r33434. 3r33418. 14. Bioquark. Country: USA. 3r33434.
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 3r33434. Bioquark 3r3434. - A company that is engaged in very ambitious research. They directly declare that they are fighting death, fatal diseases, and aging in general. The most interesting is that the company conducts research on the regeneration of the body, even after death. That is, we can say that they want to start raising people from the dead. It sounds fantastic, but however someone is already trying to do it (or at least trying to talk about it on a serious level). Of course, it is possible that all this is just a marketing ploy, but even if this is the case, then attention to the problems highlighted by them can only increase, which will definitely affect the awareness of many people about the problems in the field of medicine.
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 3r33434. 3r33418. 15. Insilico Medicine. Country: USA /Russia. 3r33434.
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Company
which is engaged in the processes of research and development of drugs, as well as aging research, with the help of advances in machine learning. Its founder is Alexander Zhavoronkov - a scientist working in the field of biotechnology, regenerative medicine and the economy of aging.
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 3r33434. 3r33418. 16. Telomere Diagnostics. Country: USA. 3r33434.
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 3r33434. 3r33300.
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 3r33434. 3r3305. Telomere Diagnostics, Inc.
Is a privately held molecular testing company founded in 2010 by a group of four scientists, including Dr. Elizabeth Blackburn, who won the Nobel Prize in Medicine in 2009 for her innovative work in the field of telomere biology. The company recently launched TeloYears, a simple genetic test that detects the cell age encoded in your DNA so you know how well you are aging. With age, telomeres shorten. To measure the length of telomeres, the company has developed its own method for quantitative analysis of polymerase chain reaction.
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 3r33434. 3r33333.
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 3r33434. Why precisely telomeres? DNA is the building block of life and is found in almost every cell of all living things “packed” into chromosomes. As is known, in humans, each of the cells (except germ cells) contains 46 chromosomes. For the organism to grow and function, the cells must divide and produce new cells in order to replace the old ones. During cell division, it is important that the chromosomes remain intact and are evenly distributed between cells. Telomeres are the end sections of chromosomes that perform a protective function in the same way that the tips of the laces protect them from disentangling. With each cell division, telomeres lose most of their telomeric DNA, the cell does not multiply and dies. Thus, the loss of telomeric DNA during each cell division acts as an hour.s aging throughout the life of the cell. Therefore, it is important to fix their length in the body.
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 3r33434. 3r33418. 17. Oisin Biotechnologies. Country: USA. 3r33434.
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 3r33434. [img]https://static1.squarespace.com/static/58f6968115d5dbcc64eb277e/t/590256baff7c50a305bf83ab/1536104740733/?format=1500w[/img]
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 3r33434. As mentioned above, aging of an organism is a consequence of cell aging. Oisin Biotechnologies engaged in the development of methods for the purification of aging cells. In 201? two goals of the organization were achieved: the creation of such a DNA that would recognize and destroy aging cells; safe and efficient delivery of this structure to cells throughout the body. At the moment, the company is engaged in experiments with their developed technology.
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 3r33434. 3r33418. 18. Elevian. Country: USA | Funding: $ 5.5M. 3r33434.
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 3r33434. [img]https://static1.squarespace.com/static/5b7168984eddec1ee06cba31/t/5b992c6af950b779d552bd0b/1544825368604/?format=1500w[/img]
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 3r33434. Studies have shown that older animals with blood transfusions of young animals experience regeneration in many tissues and organs. The opposite is also true: young animals experience accelerated aging during blood transfusions of older animals. Researchers from Elevian identified specific circulating factors that may be responsible for these effects. One example, the natural molecule, known as "growth differentiation factor 11" ("GDF11"), when injected into older mice, reproduces the regenerative effects of young blood. GDF11 supplements reduce the age-related hypertrophy of the heart, accelerate the recovery of skeletal muscles, improve physical activity, improve brain function and cerebral blood flow, and also improve metabolism. Elevian develops a range of therapeutic agents that curse GDF11 and other circulating factors in order to restore the body’s natural regeneration capacity, which we believe eliminates the underlying cause of age-related diseases.
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 3r33434. 3r33418. 19. BioViva. Country: USA. 3r33434.
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 3r33434. 3r33360.
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 3r33434. For me, This is one of the most interesting companies. Their CEO is a fairly well-known woman Elizabeth Parrish , and she is known for becoming the first woman to accept gene therapy. In 201? Elizabeth conducted two gene therapies. The first was designed to suppress age-related muscle loss caused by a protein called myostatin, which was injected into the muscles of the legs. The average person loses 50% of his muscle mass by the age of 80. This age-related muscle loss, known as sarcopenia, is associated with many age-related disorders and leads to poor quality and longevity. The second therapy was aimed at preventing telomere shortening. In September 201? it was revealed that Elizabeth has extremely short telomeres, like a man who is 60 years old. In March 201? another telomere was measured. It became known that telomeres increased by 10%. This meant that in just half a year Elizabeth’s cells had become 20 years younger. Gene therapy has restored telomere size to normal. In 201? the last measurement of telomeres was made, which, as it turned out, increased by another 10% percent of the result of 201? which is equivalent to the rejuvenation of cells for another 10 years. This result exceeded expectations. First, because so far there have been no negative effects of therapy. That is, cancer did not develop due to the perceived danger of activating the enzyme telomerase. Second, the telomeres continued to grow longer without any additional treatment. The consequence of such changes was the achievement of treatment of muscle degradation: muscle mass has increased and remains stable at a normal level for 3 years. At the moment, it is not completely known whether telomeres increase in all cells of the body. BioViva people are trying to figure it out.
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 3r33434. The company already has some finished products:
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 3r33434. 3r33333. MapMyFitness [/b] ($ 299) - DNA analysis aimed at providing information on personalization of diet and exercise.
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 3r33434. 3r33333. Whole Genome Sequencing [/b] ($ ?199) - complete DNA analysis.
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 3r33434. 3r33333. MapMyHealth [/b] ($ 379) - is also part of the DNA analysis, which aims to adjust and optimize lifestyle.
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 3r33434. Research and development continues in the field of gene therapy.
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 3r33434. 3r33418. 20. GERO. Country: Russia. 3r33434.
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 3r33434. 3r3405.
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 3r33434. 3r33410. Biotech startup and community
consisting of people from interdisciplinary areas. At the moment, the company has developed an app 3r33412. Gero Healthspan
.
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 3r33434. 3r33418. 21. Youthereum Genetics. Country: Russia. 3r33434.
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 3r33434. 3r33424.
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 3r33434. The company was founded 3r3343429. Yuri Deygin
. This is probably the most unusual startup at the moment. The company's website contains a pdf file with goals, strategies and explanations about their activities. After reading, it seems to me, there are no questions left. The main goal is to find ways to safely epigenetic rollback (epigenetic reset). I will try to explain what it is. There is a special kind of pluripotent stem cells - induced stem cells (3r3-3431. Induced pluripotent stem cells 3r3434. Or iPS). Their main property is that they can be induced from an adult cell. The iPSC technology was developed by Sinya Yamanak's laboratory in 200? which showed that the introduction of four specific genes (Oct-3/? Sox family, Klf family, Myc family - OSKM) that encodes transcription factors can turn adult cells into pluripotent cells. For this discovery, Yamanaka was awarded the Nobel Prize in Medicine for 2012. It is assumed that due to this technology it is possible to use the so-called epigenetic reprogramming. What is epigenetics, epigenetic clocks, and more is described in
Article 3r3434. by Yuri himself.
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 3r33434. So, I analyzed 21 organizations that deal with age-related diseases and the study of the aging process of the body. Perhaps I have not fully revealed the goals, research and current state of some of them in more detail. For this, it would be necessary to thoroughly study the history of news and articles released by each company, which could require an enormous amount of time, since at the moment I have no education in the fields of medicine, biochemistry, cell biology, and so on. If you are aware of any organizations dealing with such things, I would be glad to know about them. In addition, I will not give up advice on my further journey in this area from people who are engaged in similar things (bioinformatics, bioengineers, ML-recercher in medicine and biology, etc).
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